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Csilla  Ari D'Agostino

Csilla Ari D'Agostino

Csilla Ari D'Agostino
Research Assistant Professor


Office: PCD 3127
Phone: 813/240-9925



PhD, Neurosciences, Semmelweis University, Budapest, Hungary, 2008
MS, Zoology, Szent Istvan University, Budapest, Hungary, 2002


  • Exploring and testing novel applications of exogenous ketone supplements, using behavioral tests on rodent models, confocal and electron microscopy, hyperbaric experiments
  • Cell surface protein mislocalization in neurodegenerative diseases and cancer
  • Metabolic therapies for neurodegenerative diseases, seizure disorders and cancer
  • Diving physiology; psychological and physiological changes in response to extreme environments working with NASA, adaptations to extreme environments
  • Comparative neuroanatomy, cognitive, behavioral studies and sensory biology, especially focusing on giant manta rays

Publications can be found at:

Personal website:

Specialty Area

Comparative neuroscience and sensory biology, diving physiology, adaptations to extreme environments, neurodegenerative diseases, comparative cognition, cancer biology, stress

Honors and Award

Travel award from International Society of Neurochemistry (2013)

Grant from Manta Pacific Research Foundation (2013)

Grant from Manta Pacific Research Foundation (2014)

Grant from Manta Pacific Research Foundation (2015)

Research Recognition Award, The American Physiological Society Comparative and Evolutionary Physiology Section, Boston, USA (2015)

Grant from Manta Pacific Research Foundation (2016)

Grant from Quest Nutrition LLC. (2017)


Ari, C. (2009). On the brain of cartilaginous fishes: Cerebralization, astroglial architecture and blood-brain barrier composition, Lambert Academic Publishing.


Ari, C. (2013) Past, present and future of manta rays, Keynote talk at the Oceanography-2013 Conference, Manta Ray Symposium, Orlando, FL, USA

Ari, C. (2013) First evidence of long term and rapid coloration changes of giant Manta rays (genus Manta) with implications on reliability of photo identification techniques, Manta Ray Symposium, Orlando, FL, USA

Ari, C. (2013) Coloration changes of manta rays, Oceania Chondrichtyan Society Meeting, Brisbane, AU

Ari, C. (2013) Researching manta ray brains, TedXTampaBay

Ari, C. (2014) Rapid and long-term coloration changes of manta rays, American Elasmobranch Society Meeting, Chattanooga, USA

Ari, C. (2014) Manta ray research and conservation projects, DEMA show, Las Vegas, USA

Ari, C. (2015) Neuroprotective metabolic therapies by the ketogenic enhancement of the Szentgyorgyi-Krebs cycle: studies in animal models, 3rd International Congress of Deuterium Depletion, Budapest, Hungary

Ari, C., D`Agostino, D.P. (2015) Sensory and cognitive experiments on giant manta rays, American Elasmobranch Society Meeting, Reno, USA

Recent Publications

Kalman, M., Somiya, H., Lazarevic, L., Ari, C., Majorossy, K. (2013) Absence of post-lesion glial reactivity in elasmobranchs and turtles and its bearing on the evolution of astroglia, Journal of Experimental Zoology, doi: 10.1002/jez.b.22505.

D'Agostino, D., Pilla, R., Held, H., Landon, C.S., Ari, C., Puchowicz, M., Brunengraber, H., Arnold, P., Dean, J. (2013) Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats, American Journal of Physiology ;304(10): R829-36.

Poff, A., Ari, C., Seyfried, T., D`Agostino P.D. (2013) The Ketogenic Diet and Hyperbaric Oxygen Therapy Act Synergistically to Prolong Survival in Mice with Systemic Metastatic Cancer, PlosOne 8(6): e65522. doi:10.1371/journal.pone.0065522.

Ari, C., Borysov, S., Wu, J., Padmanabhan, J., Potter, H. (2014) Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiol Aging. 35 (8): 1839-49. pii: S0197-4580(14)00180-8doi:10.1016/j.neurobiolaging.2014.02.006.

Poff, A.M., Ari, C. , Arnold, P., Seyfried T.N., D’Agostino D.P. (2014) Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer, Int J Cancer. Feb 26. doi: 10.1002/ijc.28809

Ari, C. (2014) Rapid coloration changes of manta rays (Mobulidae), Biological Journal of Linnean Society, 113: 180–193. doi: 10.1111/bij.12321

Ari, C. , Poff, A.M., Held, H., Fiorelli, T., Goldhagen, C., D`Agostino, D.P. (2014) Increased TCA cycle intermediates in response to diet with Deanna protocol in ALS mouse model The FASEB Journal vol. 28 no. 1 Supplement 578.3

Ari, C. , Poff, A.M., Held, H.E., Landon, C.S., Goldhagen, C.R., Mavromates, N., D’Agostino, D.P. (2014) Metabolic therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model, PLoS ONE 9(7): e103526. doi:10.1371/journal.pone.0103526

Kesl SL, Poff AM, Ward NP, Fiorelli TN, Ari C, Van Putten AJ, Sherwood JW, Arnold P, D’Agostino DP. Effect of Sustaining Dietary Ketosis on the Hippocampal and Serum Metabolome of Sprague-Dawley Rats. March 2015, Boston, MA. The FASEB Journal, vol. 29 no. 1 Supplement 745.4.

Ari, C. (2015) Long-term body pigmentation changes on a manta ray (Mobulidae), Biological Journal of the Linnean Society, 114: 406–414. doi: 10.1111/bij.12416

Ari, C. , Decker, S., Ford, J., D`Agostino, D.P. (2015) What can we learn from deep-diving elasmobranchs to help humans adapt to extreme underwater environments? The FASEB Journal, Vol. 29: 1, Supplement 678.18.

Ari, C. , Poff, A., Landon, C., Goldhagen, C.R., Mavromates, N., Kesl, S., Ward N.P., Fiorelli T.N., Van Putten A.J., Sherwood J.W., Arnold P., D’Agostino, D.P. (2015) Metabolic therapies improve mitochondrial morphology and function, The FASEB Journal, Vol.. 29:1 Supplement 1036.10.

Kesl, S.L, Poff, A.M., Ward, N.P., Fiorelli, T.N., Ari, C. , Van Putten, A.J., Sherwood, J.W., Arnold, P., D’Agostino, D.P. (2016) Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats, Nutrition and Metabolism, 13:9. DOI: 10.1186/s12986-016-0069-y

Sajan, M., Hansen, B., Ivey, III R., Sajan, J., Ari, C. , Song, S., Braun, U., Leitges, M., Farese-Higgs, M., Farese, R. (2016) Brain Insulin Signaling is Increased in Insulin-Resistant States and Decreases in FoxOs and PGC-1a and Increases in Aß1-40.42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. pii: db151428. PubMed PMID:26895791.

Ari, C. , D’Agostino D.P. (2016) Contingency checking and self-directed behaviors in giant manta rays: Do elasmobranchs have self-awareness? Journal of Ethology, May 2016, Volume 34, Issue 2, pp 167-174.

Ari C, Laros K, Balcombe J, D`Agostino DP. 2016 Understanding the behavior of manta rays: response to a critique, Journal of Ethology, Volume 35, Issue 1, pp 149–152.

Ari C, Kovacs Z, Juhasz G, Murdun C, Goldhagen CR, Koutnik A, Poff AM, Kesl SL, D’Agostino DP. 2017 Exogenous ketone supplements reduce anxiety-related behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk rats. Front. Mol. Neurosci. 9:137. doi: 10.3389/fnmol.2016.00137

Ari C. Canfield CE; Copes N, Poff AM, Fiorelli TN, Landon CS, Goldhagen CR, Mavromates N, D’Agostino DP. 2017 The Deanna protocol supplement complex supports mitochondrial energy metabolism and prolongs lifespan in preclinical models of amyotrophic lateral sclerosis (ALS), Metabolomics, 13:55.

Kovacs, Z., D'Agostino, D.P., Dobolyi, A., Ari, C. (2017) Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats. Frontiers in Molecular Neuroscience, 10, 235.

Kovács, Z., D’Agostino, Ari, C. (2018) Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats. Front. Behav. Neurosci.12:29. doi: 10.3389/fnbeh.2018.00029

Csilla Ari, Zsolt Kovács, Cem Murdun, Andrew P. Koutnik, Craig R. Goldhagen, Christopher Rogers, David Diamond, Dominic P. D Agostino (2018) Nutritional ketosis delays the onset of isoflurane induced anesthesia, BMC Anesthesiology 18:85

Ari C, Koutnik AP, DeBlasi J, Landon C, Rogers CQ, Vallas J, Bharwani S, Puchowicz M, Bederman I, Diamond DM, Kindy MS, Dean JB, D Agostino DP. (2019) Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements. Physiol Rep.7(1):e13961. doi: 10.14814/phy2.13961. PubMed PMID: 30604923.

Ari, C., D’Agostino, D. P., Diamond, D. M., Kindy, M., Park, C., Kovács, Z. (2019) Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements. J. Vis. Exp. (143), e58396, doi:10.3791/58396.

Kovács, Z., D'Agostino, D.P., Diamond, D.M., Ari, C. (2019) Exogenous Ketone Supplementation Decreased the Lipopolysaccharide-Induced Increase in Absence Epileptic Activity in Wistar Albino Glaxo Rijswijk Rats. Front. Mol. Neurosci. 12:45. doi: 10.3389/fnmol.2019.00045